Abstract:
Objective To investigate damaging effects of dust storm fine particle(PM2.5)on DNA in lung cells of rats.
Methods Wistar rats were randomly divided into toxicosis groups and control group by intratracheal instillation.After instilled 24 hours, DNA damage of lung cells of rats was detected with single cell gel electrophoresis technique.
Results Both dust storm PM2.5 and normal weather PM2.5 could lead to DNA damage in a dose-dependent manner.Though the effects induced by normal weather PM2.5 heavier than dust storm PM2.5, there was no significant difference between them.
Conclusion Both dust storm PM2.5 and normal weather PM2.5 could lead to DNA damage in lung cells of rats.However, the dust storm PM2.5 whose airborne concentrations were much higher than that of normal weather PM2.5, so the dust storm PM2.5 should be more harmful.