Abstract: ObjectiveTo explore the associated factors with the risk of stomach cancerin a high cancerincidence area of Jiangsu province.MethodsApopulation-based case-control study including 646 cases and 1292 controls was conducted in Dafeng county,one of the high cancerincidence areas in Jiangsu province.Cases consisted of patients with newly diagnosed histologically confirmed gastric cancer.Controls were cases admitted during the study period without diagnostic gastrointestinal diseases.Univariate and multivariate non-conditional Logistic regression analyses were used to identify associated factors of stomach cancer.ResultsHot food(OR=2.2841,95% CI:1.2609~4.1376),fast eating speeding(OR=2.9668,95% CI:2.2736~3.8714),peppery food(OR=2.4875,95% CI:1.3644~4.5352),family cancer history(OR=1.4224,95% CI:1.1041~1.8325)significantly increased the risk of developing stomach cancer,while often washing grain container(OR =0.5713,95% CI:0.4429~0.7368),eating raw garlic(OR=0.6299,95% CI:0.4567~0.8687),using refrigeratory (OR=0.6256,95% CI:0.4104~0.9537),tea drinking(OR=0.4541,95% CI:0.3292~0.6263),optimistic character (OR=0.5157,95% CI:0.3147~0.8453)were protective factors for the stomach cancer.ConclusionHealthy lifestyle and dietary pattern,and healthy psychological status could reduce the risk of stomach cancerin the high cancerincidence area.