Abstract: Objectivewknow the coherence of measles,diphtheria and poliomyelitis antibody level of children with reported immunization coverage.MethodsSerum samples of 253 children born in 2001~2003 were selected from 10 villages in one county of Hunan province to compare positive rate of measles,diphtheria and poliomy elitis antibody and antibody titre of children of different age.wcompare positive rate of antibody with reported immunization coverage.Resultswe positive rate of measles,diphtheria and poliomyelitis antibody was 87.0%,42.9% and 87.0% respectively.we diphtheria antibody positive rate was low,and positive rate three kinds of antibody were all lower than reported immunization coverage(P<0.01).ConclusionIt is necessary to be alert on low immunization coverage level of diphtheria-per tusis-tetanus triple vaccine(DPT).It is recommended to assess expanding program on immunization(EPI)in an integated way by reviewing immunization coverage data assisted with serum investigation.