Abstract: ObjectiveTo understand the depression status of women who had birth defect child and its influencing factors.Also to provide evidences to guide the psychological health for women who suffered from depression.MethodsUsing questionnaire and Center for Epidemiological Survey,Depression Scale(CES-D)to interview 151 women who had birth defect child in Shanxi province where had the highest birth defect prevalence and select 303 women who had healthy child as control group.ResultsAmong all of the women who had birth defect child,53% of them had depr ession and 26% had serious depression.Linear regression showed self-assessment of the healthy status and economic conditions,sense of happiness and external factors such as chemical plant existing or not,independent kitchen and debt of the family were remarkable to depression.ConclusionThere is significant difference between women who had birth defect child or not.It is necessary to provide psy chological consultatin for women who used to have birth defect child.