Abstract: ObjectiveTo study factors influencing quality of life of type 2 diabetes mellitus in order to provide reference for making reasonable measures of improving their quality of life.MethodsQuality of life of 697 subjects with type 2 diabetes mellitus was evaluated by Chinese normal audit diabetes-dependent quality of life(CN2ADDQOL),and structural equation model was used to study factors influencing quality of life of type 2 diabetes mellitus.Results8 factors including age,occupation,earning,course of disease,expenditure on disease,phase of disease,complications and life event,had statistical significance(P<0.05)and influenced quality of life of type 2 diabetes mellitus.Patients with older age,intense brainwork,tense occupation,high earning,long course of diseases,high expenditure on disease,complication and irritant life event,had poorer survival quality.ConclusionIt is very necessary for type 2 diabetes mellitus to avoid intense brainwork and tense occupation, take in effective therapy,prevent complications,and keep optimistic attitude in order to improve survival quality.