Abstract: ObjectiveTo investigate the capacity of public health emergency response among the staff from Centers for Disease Control and Prevention(CDC)and explore the influential factors in Hubei.MethodsAnonymous investigation was conducted among 173 staff in CDC in Hubei,and multifactorial Logistic regression model was applied to data analysis.Results The response capacity of staff was promoted after crisis of SARS in CDC.However,the unsuitable disposition of staff and lower capacity regarding public health emergency response did not always satisfy the requirement of current situation.Factors influencing on the capacity regarding public health emergency response might include:levels of work(OR=3.610),standard of culture(OR=2.685),major of graduation(OR=2.03),department of work(OR=2.069),length of training time (OR=2.156)and levels of training(OR=4.122).ConclusionThe capacity of public health emergency response was obviously insufficient to CDC's staff in Hubei,which would be promoted by perfecting disposition of staff and carrying outhigher level training of specialized skill.