Abstract: Objective A Case-control study was finished in 2006 to analyse the major risk factors of hypertension combined with obesity.Methods 372 outpatients of two community hospitals were comprised of case group while 473 healthy people in the same community were compared as control group.All of subjects were surveyed by same questionnaire,mean-while some physical and laboratory examinations were completed.The univariate analysis and Logistic regression analysis were used to screen the major risk factors.Results The present study showed that the risk of hypertension with obesity were increasing with age and the risk was higher in men than women.Genetic was major risk factor,such as father's obesity(OR=5.04 95%CI=3.12～8.14),father's hypertension(OR=2.4595%CI=1.81～3.35),mother's obesity(OR=2.5595%CI=1.78～3.64)and mother's hypertension(OR=2.1495%CI=1.60～2.86).In addition,some behaviors also were the risk factor,including salty diet(OR=2.4595%CI=1.82～3.29),drinking(OR=1.92 95%CI=1.37～2.68).However,going to work by bicycle or on foot(OR=0.64 95%CI=0.46～0.89)and milk intake(OR=0.7395%CI=0.55～0.97)were protective factors.Moreover,the prevalence of dyslipidemia in case group was higher than that in control group(P<0.01),which suggested thathypertension combined with obesity could increase the risk of dyslipidemia.Conclusion Abstaining from smoking,reducing salt consumption,moderate exercise and rational diet should be the major precautionary measures.The primary and secondary prevention should be enhanced for higher risk population with genetic risk.