Abstract: Objective To investigate the effects of gene-interaction on the risk of lung cancer.Methods Case-control study was performed,in which 227 controls without tumor were matched to the 227 original lung cancer cases.The polymorphisms of C YP1B1,C YP2C19,C YP2D6,C YP2 E1,GSTM1,GSTT1,GSTP1,mEH,NQO1,XRCC1,XRCC3,hO GG1,NA T2,XPD were detected and gene-gene interactions were analyzed by Logistic regression model.Results There was a synergistic effect on development of lung cancer between C YP2C19 mutaion genotypes and NQO1 mutation genotypes,mEH-exon3 mutation genotypes and NQO1 mutation genotypes,respectively.No other gene-gene interactions were found.Conclusion Analysis of gene-gene interactions would be helpful to screen high-risk group.A large range samples study should be perfomed to analyze the interactions among multi-genes.