Abstract: Objective To study the relationship between esophageal cancer(EC)on Xingjian Kazakh and Methyleneteterahydrofolate reductase(M THFR)C677 T gene polymorphisms.Methods A 1:2 matched case-control study was conducted with 92 cases of exophageal cancer and 184 population-based controls.M THFR genotypes were detected by PCR-RFL P.Results The genotype frequencies of EC group was different from that of controls group(P<0.05).The allele T of M THFR had a 1.709-fold95%CI:1.115～21.67increased risk of developing EC compared with those who had allele C.Multiple Cox regression analysis showed that:the individuals with 677CT genotype had a 7.216-fold95%CI:1.552～33.554increased risk of developing EC compared with those who had 677CC genotype.It could reduce incidence of esophageal cancer to eat fruit often.(O R:0.245;95%CI:0.070～0.850.Interaction analysis showed that taking fruit could reduce incidence of esophageal cancer if the carriers of the M THFR677C/T genotypes.Conclusion The polymprphism of M THFR C677 T was associated with developing EC in Xinjiang Kazakh.This finding suggests gene-environment interaction and is role in the susceptibility to EC,either folate deficiency of M THFR polymorphisms with risk of EC.