Abstract: Objective To understand the prevalence and risk factors of chronic diseases in families with HIV/AIDS.Methods With stratified random sampling method,718 families were questionaired(289 HIV+families and 429 HIV-families)in 4 provinces.Results Rates of families with chronic diseases were 11.04% and 12.89% in total HIV+and HIV-family group respectively,and no statistic significance was found.Number of chronic disease patient/perfamily was not found significantly different between HIV+and HIV-family group in drug use and paid blood do nors(PBD)families,also no statistic significance for the rate of family with one or more kinds of chronic diseases families between HIV+and HIV-family group.The disease spectrum was almost the same in HIV+and in HIV-families.8 kinds of chronic diseases were self-reported,only incidence of chronic lung-heart/bronchitis was found stat istically significant between HIV+and HIV-family group(1.9% and 3.9% respectively).Unconditional Logistic regression analysis revealed that family size and low annual family income(0~2000 yuan)were significantly related to occurance of families with chronic diseases.Conclusion No significance was found for both the rate of families with chronic diseases and the number of chronic disease patient/perfamily between HIV+and HIV-family groups in druguse and PBD populations.Prevalence of families with chronic diseases was significantly related with large family size and low economic income.