Abstract: ObjectiveTo investigate relationship between excessive iodine intake and immunolgically mediated disease of mice thyroid organ specificity.MethodsBABL/C mice were assigned into 6 groups and given taper water or drinking water including different doses of iodine.The iodine concentrations were,1500,3000,6000,12000 and 24 000μg/L respectively.Three months later,serum of maternal mice was used for thyroid hormone level determination and thyroid used for histological examination.ResultsIn excessive iodine intake groups,mice showed diffused colloid goiter.Serum TT4、TSH level was significantly higher,and TT3 level lower than control group,thyroid IgG antibody and serum TSHRab significantly higher than normal control group from 6 000μg/L group.ConclusionExcessive iodine intake induces A ITD.The threshold level of iodine induced embryo toxicity in this study is 6 000μg/L〔0.75 mg/(kg·bw)〕.This kind of autoimmune reaction prone to humoral immunity.