Abstract: ObjectiveTo study the efficacy of the TR/Patoc 1 slide agglutination assay for vaccination new pentavalent whole cell vaccine for leptospirosis.MethodsUsing TR/Patoc 1 slide agglutination assay to detect the searial of serum specimens of 100 healthy people after vaccination for leptospirosis and comparing with the microsopic agglutination test(MAT).ResultsBoth basic immunizaton and 20 days after the enhanced immunization,their positive seroconversion rates were higher than 90% in TR/Patoc 1 slide agglutination assay,they were not signficantly different between slide agglutination assay and MAT,the antibody titer was greatly lower in 90 days after basic immunization.ConclusionThe TR/Patoc 1 slide agg lutionation assay was one of useful assays in evaluation the lately immune efficency of leptospira vaccination.