Abstract: ObjectiveTo study the protective effects of taurine combined with naloxone on rats with brain contusion.MethodsWistar rats were randomly divided into five groups,including control group,brain contusion model group,taurine group,naloxone group and taurine combined with naloxone group respectively.In the end of the study,the content of intracellular calcium,the activity of SOD and GSH-Px and content of malondialdehy de(MDA)in the cortex of contusion side and excitatory amino acids and lactic acid in cerebr ospinal fluid were detected.ResultsCompared with model group and the other treated groups,the contents of intracellular calcium,MDA in the cortex of contusion side and excitatory amino acids and lactic acid in cerebrospinal fluid in the taurine combined with naloxone group significantly reduced,and the SOD activity(P<0.05)inc eased.ConclusionThe treatment of taurine combined with nalox one can protect effectively the brain with contusion.