Abstract: ObjectiveTo study the inhibitory effects of soybean hypocotyl extracts on oxidation of plasma lipoproteins in diabetic rats.MethodsTotal glycosides were extracted from soy bean hypocotyl,then detected with high-performance liquid chromatography(HPLC).Diabetic rats were given feed containing 100 g/kg soybean hypocotyl extracts for 20 weeks,and lipid peroxide(LPO)levels of lipoproteins and susceptibilities of lipoproteins to oxidation were investigated.ResultsLPO levels of plasma,LDL and HDL fractions of the experimental rats were(17.1±2.2),(2.6±0.5)and(3.9±0.7)mol/L, respectively after soy hypocotyl extract intake,which were significantly decreased than those of control rats(21.4±3.5),(3.4±0.8)and(5.4±0.9)mol/L;lag phage of LDL oxidation curve in vitro was(120±36)min,noticeably prolonged than that of of control rats(83±27)min.ConclusionIt is suggested that soy hypocotyl extracts,which can decrease the peroxidizability of lipoproteins and promote resistance to LDL oxidation,may be useful in prevention and treatment of diabetes mellitus and diabetes-associated diseases.