Abstract: ObjectiveTo study the effects of different doses of manganese on activities of GS and PAG in the rat striatum and the activities of SDH and Na⁺-K⁺-AT Pase in pallium in order to explore the cell molecular mechanism of man ganese-induced exeitotoxicity.MethodsThe Wistar rats were divided into four groups by weight at random.The first group was the control group which was given peritoneal injection(i.p)of 0.9% NaCl;the second to fourth groups were respectively given i.p of 8,40,200 μmol/kg MnCl₂.The capacity of injection was all 5 ml/kg.After 25-days administration, the activities of GS and PAG in the rat striatum and the activities of SDH and Na⁺-K⁺-AT Pase in pallium were determined.ResultsAccompanied with the incrasing of treated Mn dosage,the activities of SDH and Na⁺-K⁺-AT Pase in pallium decreased,the activities of SDH and Na⁺-K⁺-AT Pase in pallium in 200 mol/kg MnCl₂ group decreased significantly with a dose-response relationship;the activity of PAG in corpor a striatum increased and the activity of GS in corpora striatum decreased in 200 mol/kg MnCl₂ group;the activity of GS in corpor a striatum decreased significantly,however,the activity of PAG in corpora striatum increased significantly.ConclusionMn may decrease the activities of SDH and Na⁺-K⁺-ATPase in pallium and the activity of GS in corpora striatum,and increase the activity of PAG in corpora striatum,which led to disrupt glutamate metabolism.