Abstract: Objective To generalize a theoretically scientific basis on empirical antimicrobial selection for ur inar y tract in fectio ns(UT I),we analy zed correlative resistance of uropathogens to antibiotics of types.Methods Uropathogens of U T I patients wer e collected from 15 tert iary grade A hospitals in Hubei Ant imicrobial Resistance Surveillance Networ k,and then antimicrobial susceptibility testing was done o n uniformity project.Related statist ical analysis were made with softwares SAS 6.0 and WHON ET 5.3.Results Gram negative bacteria was the most frequently uropatho gen.There was generally signifi cant positive correlation between resistance to one antibiotic and to another.Moreover,did rise the highresistance rates of either gram negative strains or grampositive ones to many tested antibiotics.Only nitrofur antoin resistance of lowand stable rates had either the faintest or no significant correlation with resistance to any other antibiotic.Conclusion Nitrofur antoin should be the preferred agent for empirical UTI treatment.