Abstract: Objective To explore congenital heart diseases(CHD)in offspring in association with maternal environmental factors.Methods A 1:1 case-control study was carried out to investigate 115 pairs children and their parents.The possible risk factors were analysed by simple and multiple factors Logistic regression.Results 4 factors were related with the occurrence of CHD in offspring:maternal exposures to pesticides in the early stage of pregnancy(OR=7.316,95%CI:1.196～ 44.731),catching a cold in the early stage of pregnancy(O R=4.806,95%CI:2.092～1.104),suffering from diseases during pregnancy(OR=2.851,95%CI=1.189～6.838),depressed or nervous condition during pregnancy(OR=3.318,95%CI=1.829～6.018).Conclusion The occurrence of CHD was related with maternal exposures to pesticides,catching a cold,suffering from diseases,depressed or nervous condition in the early stage of pregnancy or during the pregnancy.