Abstract: e case-contr ol study,we enrolled 71 patients with angina and 164 controls.All patients and controls were genotyped by po lymerase chain reaction and allele-specific oligonucleotide techniques for the ICAM-1 polymorphism.ResultsConventional cardiovascular risk factors including ag e,sex,BMI,smoke,blood pressure and blood lipid showed no significant difference between case and control group(P>0.05).The distribution of genotype(KK,KE,EE)in angina and control groups was 28(39.4%),30(42.3%),13(18.3%)and 40(24.4%),65(39.6%),59(36.0%),respectively.K allele gene correlated with angina and peo ple with KK or KE genotypes had 2.525 times high risk of angina than those with EEgenotype.ConclusionThere is relationship between the K469E polymorphism of ICAM-1 gene and angina,which may be a potential factor influencing the risk of coronary heart disease(angina).