Abstract: ObjectiveTo investigate Helicobacter pylori infection in the population of Tianzhu areas,Gansu province.MethodsWith 1495 subjects selected in Tianzhu area,serologic H.pylori-Ig-Gexamination and ¹⁴-C-U BT were carried out.ResultsThe H.pylori infective rate was 74.0%.Neither nationalities of Han and Zang nor gender had significant difference in H.pylori infective rate(P>0.05).In the population of mountain area,the H.pylori infective rate was significantly higher than that of in the city area(P<0.01).H.pylori infectived rate increased along with the age,and reached the hig hest value in age group around 30 years.H.pylori infective rate in the population of cadre was significantly lower than that of in worker,peasant,doctor and nurse(P<0.05).H.pylori infection had a familial clustering trend.The residents drinking water from pond,canal and river had a significantly higher prevalence of H.pylori infection than those with tap water(P<0101).H.pylori infection was correlated with the over all economic status,the custom of sanitation and symptom of upper digestive tract disorders(P<0.05).ConclusionH.pylori infective rate was high in Tianzhu area and significantly related with factors such as economic status,sanitation habit,drinking water sources and symptom of upper digestive tract disorders.