Abstract: Objective To investigate prevalence and risk factors of cognitive impairment among the elders in Guiyang city.Methods Using multistage sampling,elder people(≥60 years old)were surveyed in urban community of Guiyang by MMSE questionnaire.Results 3.75 elder peoples'cognitive function was evaluated.We found that 647(20%)had cognitive impairment,including mild 465(14.4%)and serious cognitive impairment 182(5.7%).The cognitive impairment prevalence in the female was higher than that of in the male.The patients with cognitive impairmenthad multi-domain impairment.In multi-regression analysis,the score of MMSE was related to educational attainment,score of ADL,age,and gender.Conclusion Elder people's cognitive impairment is serious in urban community of Guiyang.Elder people's cognitive impairment is related to grade of education,age,and gender.It is important to inspect elder peoples'cognitive function early and to improve their quality of life.