Abstract: Objective To investigate the expression of HSP 70 mRN A in hippocampus and cortex after cerebral ischemia and reperfusion in rats,and to explore regulative effect and mechanism of basic fibroblast growth factor(bF GF)on HSP70 mR NA in braintissue.Methods The model of middle cerebralartery occlusion was performed with intraluminal filament blockade.The expression of HSP70 mRNA and cell apoptosis in hippocampus and cortex was detected with RT-PCR method and TU NEL method.Results The expression of HSPT 0mRN A in hippocampus and cortex was increased after cerebral ischemia and reperfusion.The expression of HSP70 mRNA in bF GF group was increased,but cell apoptosis was decreased.Conclusion The results indicate that bFGF depress cell apoptosis and participate in the regulation of expression of HSP70 mRNA in ischemic neurons.