Abstract: Objective To observe the effects of L-Carnitine(L-CN)on FP G and FFA in diabetes mellitus(MD) rats.Methods Thirty-six adult Wistar rats were divided into three groups by randomized blocks design.The DM group and L-CN group were given intraperitoneal injection STZ(65 mg/kg·bw),and the FP G was measured after seventy-two hours.The L-CN group was given intraperitoneal injection L-CN(250 mg/kg·bw)meanwhile,the others were given intraperitoneal injection sterile water as control.During six weeks observation schedule,FP G,BW and FFA were measured regularly.Results The achievement ratio of DM model by intraperitoneal injection STZ was 91.7%.After six weeks,the FFA between three groups showed statistical difference(P<0.001),and the FP G did not showstatistical difference(P>0.05).Conclusion The achievement ratio of DM model by intraperitoneal injection STZ was high and stable.The L-CN could decrease FFA,as well as BW,but could not effect FP G.