Abstract: Objective To evaluate the epidemiological effect of comprehensive intervention measure on HFRS.Methods Eight counties(districts)with the annual continuously high HFRS incidence,and the incidence above 30/100 000 in 2004,were selected as experimental sites in Liaoning province from 2002 to 2004,with the aid of experimental epidemiological method,to evaluate the effect of comprehensive measure predominated by vaccine immunization.Results Since the imple2 mentation of the comprehensive measure in 8 counties(districts),the incidence rate dropped continuously from 57.72/100 000 before intervention to 5.09/100 000 after intervention from 2005 to 2007.The effect index was up to 11.52,with the protection rate up to 91.32%.Meanwhile a good economic benefit was achieved,the cost effectiveness ration was 9.20.Conclusion The comprehensive HFRS intervention measures are effective in epidemiologic and economic benefit.