Abstract: Objective To investigate the association between abnormal hilit(according to diagno sticcriteria of Uigurmedicine theory and WHO diagnostic criteria)and the seroton in transporter(5 HTT)genepolymorphisms in promoter(5 HTT LPR)and the variable number tandemrepeats(VNTRs)in intron2(5 HTTVN TR).Methods The patients were divided into four different body fluids groups according to Uigur medicine theory.Polymerase chain reaction(PCR)was used to detect genotype and allele frequencies of 5 HTTLPR and 5 HTTVN TR gene polymorphisms in 102 patientswith abnormal black savda,44 patients with other abnormal hilit and 45 normal control subjects.Results No significant difference for the SS geno type frequency and difference of Sallele frequency of 5 HTTL PR were revealed bewteen patients with abnormal black savda(39.21% vs 40.00%,65.19% vs 62.22%)and patients with other abnormal hilit(4.90% vs 40.00%,65.90% vs 62.22%)and normal control subjects.The normal control subjects tended to be more of L/L genotype(15.56%)than patients with abnormal black savda(8.83%)and patients with other abnormal hilit(9.10%).However,there was no difference in the distribution of 5 HTTV N TR(12/12,12/10,10/10)bewteen patients with abnormal black savda(74.50%,20.59%,4.91%)and patientswith other abnorm al hilit(75.00%,20.45%,4.55%)and normal control subjects(77.77%,17.7%,84.45%).On the other hand,no significant difference in the geno type frequency and the alle le frequency of 5 HTTW PR and 5 HTTL PR was revealed between patients with abnormal black savda and patients with other abnormal hilit(P>0.05).Conclusion 5 HTT LPR L/L geno type may be a protective factor for abnormal hilit.No corelation was found between polym orphisms of 5 HTT gene and patients with abnormal hilit.