Abstract: Objective To establish the animal model of damp-heat syndrome of pneumonia caused by influenza virus infection for providing reliable model for traditional Chinese medicine in the treatment of dampheat syndrome.Methods Mice were randomly divide into three groups:control group,virus infection group(infected with influenza virus),model group(rich fatty and sweet diet+humid heatenv ironment+infected with influenza virus).RT-PCR was used to detect the quantity of virus in mice lungtissue.Anus temperature,blood fat,levels of lung pathological changes of the mice in different groups were compared.Results The average body weight of the mice in control group,virus group,model group was 21.5±0.91g,19.44±1.55g,22.16±0.94g,respectively,with significant difference(P<0.05).The level of anus temperature was 35.8±0.4℃,35.6±0.3℃,36.6±0.4℃,with significant increase in model group(P<0.05).Compared to other groups,the blood fat level of model group obviously raised.The lung index and lung pathological changes of the model group and virus infection group were significantly different compared to the control group(P<0.05).Conclusion The model was similar to damp-heat syndrome group in pathogenic conditions,cardinal symptom and signs.The method is simple and easy to establish with potential application.