Abstract: Objective To investigate prevalent chanacteristics of hand food mouth disease(HFMD)and the effect of no socomial infection(NI)management on the epidemic of HFM D.Methods Epidemiological investigation on 132 HFMD cases was conducted from May to July,2008,and the data of measures on NI prevention and control was collected and analyzed.Results The major pathogen of the epidemic was EV 71.The cases were mainly children under three years(68.2%) with mild symptoms and even gender distribution(65 males and 67 female cases).All 132 cases had skin rash and 2 cases had brainstem encephalitis with a total fatality rate of 0.76%.There was only one NI case occured,ad the NI rate was sign ificantly lower than that of in other hospitals during the same period.Conclusion The HFMD could be effectively prevented with strict NI prevention measures.