Abstract: Objective To explore epidemiologic characteristics and influence factors of syphilis in Jiangsu province based on the data of six STD surve illance areas from 2005 to 2007 and to provide the evidence for further control of the disease.Methods Registe red cases of syphilis were collected from surveillance a reas and the data was analysed and the case investigation was also performed.Results The number of syp hilis screening in clinics showed an increasing of 21.6% and 84.2% in 2007 and 2006.The correct diagnose ratios for congenital syphilis,primary syphilis,secondary syphilis and latent syphilis were 0%,56%,63%,and 48%,respectively.29.8% of the latent syphilis patients were older than 50 years.65% of 54 doctors with qualified response acquired correct diagnostic criterion of syphilis and only 17% of 30 doctors knew the crite ion for conginital syphilis.Conclusion The measures of enhancing the STD knowledge through education should betaken in order to control the epidemic of syphilis in Jiangsu province.