Abstract: ObjectiveTo survey the prevalence and type distribution of human papillomavirus(HPV)infection in women of Datong.MethodsA total of 931 cervical specimens from women attending routine Pap smear cytology screening were subjected to HPV detection and geno typing with PCR-LA assay.ResultsThe overall HPV prevalence was 18.6% in normal specimens,60.2% in specimens with light epithelial internal lesion,69.2% in severe epithelial internal lesion,and 84.6% in specimens with squamous cell carcinoma(SCC),respectively.High risk HPV infections were more prevalent than low risk HPV types(P<0.05).The peak of high risk HPV infection was foundin subjects of 18225 years old.The prevalence of HPV was 15.8%,4.7%,3.8%,and 1.8% for HPV -16,-58,18,and -52 in all participants,respectively.But In SCC,HPV 2.6(61.5%),2.8(11.5%)-58(7.7%),-52(3.8%)and -33(3.8%)were prevalent types.Conclusion The study demonstrated the geographic variability of oncogenic HPV distribution in Datong,China.