Abstract: ObjectiveTo investigate serum pepsionogen(PG)level in health persons and patients with chronic gastric disease or stomach cancer.MethodsSerum PG level was detected by TRFIA.The correlation between the levels of serum PGⅠ,PGⅡ and PGⅠ/PGⅡ and the mucosal changes in the patients with chronic gastropathy was analyzed.ResultsThe normal reference range of PGⅠ,PGⅡ and PGⅠ/PGⅡ was 60-252μg/L,≤27.9μl/L and PGⅠ/PGⅡ≥6, respectively.The level of serum PGⅠ,PGⅠ/PGⅡ in male were significantly higher than those of in female(P<0.05).PG Ⅱ had no significant difference in gender.There was a significant decrease in PGⅠ/PGⅡ ratio along with the increase of age.The level of serum PGⅠ gradually reduced with the progress of chronic superficial gastritis(CSG),chronic atrophic gastritis(CAG),and gastric cancer(GCa).The SCa group showed a high detection rate of PGⅠ≥240μg/L and ≤60μ g/L.The possitive rate of PGⅠ≥240μg/L was significantly higher in gastriculcer(GU)group.The ratio of serum PGⅠ/PGⅡ in CAG group and SCa group were signcficantly lower than other groups.Serum PGⅠ≥240 or ≤60μg/L and PGⅠ/PGⅡ≤6 were good cut off value for the screen of GCa.ConclusionThe serum PG level showed a skew distribution and significantly rose with sex and gastric mucosal changes.