Abstract: ObjectiveTo develop and evaluate the quality of life instmment for chronic pulmonary heart disease (QL ICD-PHD).MethodsThe programmed decision-malong method was used to develop the scale.The reliability, validity and responsiveness of the instrument were evaluated by analyzing the data from 120 patients with chronic pulmonary heart disease Statistical descriptions, Pearson's correlation coefficient, exploratory factor analysis, structural equation model, paired-samplest test were used in the analysis.ResultsThe QLICD-PHD was developed with a 30 items general module and a 21 items specific module Most of correlation coefficients between each item and its domain were above 0.5, and greater than the correlation coefficients between the item and other domains The exploratory factor analysis and structural equation model showed good validity of the instrument The Cronbach's Alpha in each domain and total score were greater than 0.75.The test-retest reliability coefficients were greater than 0.927, and split-half reliability coefficients were greater than 0.712 The instrument had good reliability.Pairedt test and standardized response means between before and after treatment showed good responsiveness of scale.Most of patients could finish the questionnaire in 15 minutes.ConclusionThe QLICD-CPHD is valid, reliable, sensitive and reasonable operation in clinical settings, and it can be used to assess quality of life for patients with chronic pulmonary heart disease.