Abstract: ObjectiveTo analyze prevalence and risk factors of coronary heart disease among senior intellectuals in Hefei and to provide reference for prevention and control of the disease Metbods A total of 4726 subjects above 35 years old were selected with cluster sampling The prevalence of coronary heart disease in different gender and age groups, and factors related to the disease were analyzed with non-conditional logistic regression Results In the survey, 256 coronary heart disease cases were identified with a prevalence of 5.6%.The prevalence was 5.1% in the male, and 6.9% in the female(χ²=6.126, P<0.05).The prevalence of coronary heart disease increasedwith age(male: χ²=149.056, P<0.001; female: χ²=111.099, P<0.001).Multi-variate logistic regression analysis showed that factors associated with coronary heart disease were age (OR=3.627, 95% CI=2.905-4.529, P=0.000),gender(OR=0.692, 95% CI=0.501-0.955, P=0.025),family history of coronary heart disease (OR=2.347, 95% CI=1.656-3.327, P=0.000),hypertension (OR=1.537, 95% CI=1.144-2.064, P=0.004),waist-hip ratio (OR=1.463, 95% CI=1.091-1.961, P=0.011) and salt intake(OR=1.236, 95% CI=1.009-1.516, P=0.041).ConclusionThe prevalence of coronary heart disease in senior intellectuals in Hefei was higher and comprehensive intervention measures should be taken against the risk factors of the disease.