Abstract: ObjectiveTo investigate the present situation and related factors of quality of life in mfiddle age intellectuals and provide the basis of health protection.MethodsThrough stratified sampling, 1 315 persons aged from 40-60 and engaged in different profession were investigated with the self-compliled scale and WHOQOL-REF.ResultsThe quality of life in middle age intellectuals was not ideal 14.9% of persons investigated were with lower quality of life The domain with the lower and lowest score were mentality and environment.The affecting factors of quality of life were education, sleeping time, physical exercise, disease in two weeks, chronic disease, medical expenditure.The result of multifactor analysis showed that the influence factors of quality of life from strong to weak were physical exercise, two-week disease, chronic disease, medical expenditure, and education.ConclusionThe quality of life in middle age intellectuals is not ideal.The main reasons are worse mental health status, bad life environment and education.