Abstract: ObjectiveTo evaluate the effect of diphtheria control during different periods in Binzhou city.MethodsDescriptive epidemiology was adopted for analysis of the epidemic situation of diph the ria,the vaccination rate of diphtheria toxoid vaccine,the population mimunity level, and control effects from 1951 through 2008.ResultsSince the planned mimunity was implemented,the vaccination rate of diphtheria toxoid vaccine was kept at 93.45-95.67%;the mimune successful rate and the diphther ia antibody level were kept at 93.63-94.30% and 89.40-89.54%.A total of 34186 ineidences and 2325 death cases were reduced in the past 38 years since the diphther ia toxoid vaccine was regularly vaccinated in 1970 with the annual average reduction of 900 incidences and 6.1 deaths.No diphtheria case occured since 1978.ConclusionVaccina ting diphtheria toxoid vaccine is one of the comprehensive measures of diphtheria prevention.The diphtheria incidence is controlled effectively in Binzhou city.