Abstract: Objective To study hepatic and renal oxidative damage in mice exposed to organic extraction of maize from sewage irrigation area.Methods Organic extractions were obtained from maize collected in pollution area and contol area with supersonic method Fifty mice were lavaged with the extractions once a day for 14 days and then the contents of malonaldehyde (MDA)，total superoxide dismutase(T-SOD)，glutathione-peroxide(CSH-Px) in liver and kidney tissues of the mice were deteun fined.Results Compared with the reagent control group,T-SOD and CSH-PX in the liver were decreased in the high-dose group(P<0.01);T-SOD of the kidney were decreased T-SOD，CHP-PX of the liver were decreased in the mice of high-dose group(P<0.05).Conclusion Organic extraction from maize from sewage irrigation area could induce hepatic and renal oxidative damage in mice.