Abstract: Objective To explore the association of apml gene polymoiphism sand ischem is stroke.Methods A casecontrol studywas conducted Taqman probe technology of RT-PCR was applied to detect the genotype frequency of SNPs (rs266729 and rs2241766) of apmlgene in 357 newly diagnosed ischem is stroke cases and 345 health controls Logistic regression was used to evaluate the relationship between each genotype and ischemic stroke.Results The mutaion of rs2241766 (T→G) increased the risk of ischem is stroke (OR=1.55,P=0.005).The gene polymoiphism of rs266729 was not related to the risk of ischem is stroke (OR=1.13,P=0.57).However,the genotype GG of rs266729 increased the risk of ischem is stroke in female population (OR=3.25,P=0.04).Conclusion The variance of rs2241766 in apml gene was related to the risk of ischem is stroke in Han nationality of northeast China and the genotype GG of rs266729 possibly increased the risk of ischem is stroke in female Han nationality of northeast China.