Abstract: Objective To investigate the efficacy ofLaurencia extract(LET) combinedwith vitamin E(VE) on prevention and treahn ent of alcoholic liver disease in rats and its possible mechanism.Methods Sevenly male wistar rats were randomly assigned to seven groups A Icohol model group was orally given with alcohol of 12 mL/kg·bw.Blank group was orally given with distilled water Vitamin E group was orally supplemented with VE 30mg/kg·bw.Low,medium and high-dose combination LET group were orally supplemented with 25,50,100mg/kg·bw LET and VE 30mg/kg·bw，respectively.C coup of positive control was fed with diamm onium glycyrrhizinate of 200 mg/kg·bw.Except for blank group,the other groups were orally given with alcohol of 12 mL/kg·bw as model group.All rats were treated for 6 weeks Six weeks later,the blood and hepatic tissue of the rats were collected.The level of alanine aminotransferase (ALT)，aspartate aminotrans-ferase (AST)，triglyeride (TC)，cholesterin (CHO)in plasma,the activities of superoxide discoutase (SOD)，glutothione-peroxidase (CSH-Px)，and the content of malanydiadehyde (MDA)in hepatic tissue were measured by biochemical methods with kits.Results Compared with model group,the contents of ALT,AST,TC in plasma of medium and high-dose combination group decreased(P<0.05).The contents of CHO in plasma of high-dose combination group decreased(P<0.05).The contents of CSH-Px and SOD in hepatic tissue of medium and high-dose combination group decreased(P<0.05).In high-dose combination group,the contents of MDA in hepatic tissue ofmedium and high-dose combination group decreased (P<0.05).Conclusion The Laurencia extinct coin bined with vitamin E shows protective effect on liver damage inducecd by alcohole in rats.