Abstract: Objective To detect and analyze biochemical parameters of blood and urine among people exposed to coal burning arsenic pollution for early prev ention and treatment of arsenic poisoning.Methods Biochemical methods were used to detect 31 blood and urine biochemical parameters in 185 subjects exposed to arsenic in Xingren county of Guizhou province and 65 subjects of control group from the area without arsenic pollution.Results For 18 blood parameters reflecting hematological alteration,the red blood cell(RBC,4.09±0.73×10¹²/L),hemoglob in concentration(HGB,122.35±23.54 g/L),hemoto crit(HCT,35 85±7.09%)and mean platelet volume(MPV,1.02±0.14 g/L)contents decreased significantly while mean corpuscular hemoglob in concentration(MCHC,351.38±12.15g/L)increased significantly(P<0.01) among subjects exposed to arsenic pollution.For 13 items of blood and urinebio chemical parameters reflecting the liver and kidney function,only serum crea tinine(SCr,134.14±51.73 μmol/L),bilirubin(BIL,15.2%)and leucocyte(LEU,17.9%)positive rates were statistically significant(P<0.05).Conclusion Coalburning arsenism has certa in mipact on human blood system and liver and kidney function.Regular and selective determination of the abnormal biochemical parameters in combination with glutathione Stransferase(GSTs),β₂ microglobulin(β₂ MG)are beneficial to early identification of arsenic caused hematological liver and kidney mipairment.