类风湿及红斑狼疮与PTPN22基因多态性关系

Association of 1858C/T gene polymorphisms of protein tyrosine phosphatase-22 with rheumatoid arthitis and systemic lupus erythematosus

摘要: 目的探讨蛋白酪氨酸磷酸酶N22(Prote in Tyrosine Phosphatase-22,PTPN22)基因1858C/T多态性与贵州省汉族人群类风湿性关节炎(RA)及系统性红斑狼疮(SLE)的相关性.方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,分析110例RA患者及98例SLE患者与120例正常对照组的PTPN22基因1858C/T多态性.结果 RA组、SLE组及正常对照组的PTPN22 1858C/T基因型均为CC型,1858C等位基因频率均为100%,未发现PTPN22基因1858C/T多态性.结论 PTPN22基因1858C/T多态性与贵州省汉族人群RA及SLE无关.

Abstract: Objective To probe the association of 1858C/T genepolym orphisms of protein tyrosine phospha tase-22(PTPN 22)with rheuma toid a rthitis(RA)and systemic lupusery them a tosus(SLE)in Han population in Guizhou province.Methods The 1858C/T gene polym orphism was analyzed with polyme rase cha in reaction restriction fragment lengh polymorphism(PCR-RFLP)in 110 patients with RA,98 patients with SLE and 120 healthy controls.Results The genotype of PTPN 22 1858C/T in RA,SLE and healthy controls were CC type,and the +1858C alle led is tribution was 100%.PTPN 22 1858C/T polymorphism was not found in RA patients,SLE patients and the controls.Conclusion The 1858C/T genepolymorphism of PTPN 22 was not associated with RA and SLE in Han population in Guizhou province.