Abstract: Objective To explore the anti-tumore ffect of Korean pine cone lamella polysaccharide.Methods Sixty mice were implanted with S₁₈₀ tumor cell and randomlly divided into 6 groups:normal saline group,cyclophosphamied group and 4 Korean pine conelamella polysaccharide groups separately.Every group had 5 male and 5 female mice.Twenty-four hours after the implantation,the mice were given gavage treatment once a day for 10 days.The tumor inhibition rate,spleen index,thymus index of the mice were observed and body weight,tumor,spleen,and thymus were weighted.Results The Korean pine conelamella polysaccharide had ant-itumor effect obviously(P<0.05).It could increase spleen index and thymus index of the mice implanted with S₁₈₀ tumor cell(P<0.05).Conclusion The Korean pine conelamella polysaccha-ride has ant-itumo reffect with the strength similar to that of cyclophosphamide.