Abstract: Objective To study the relationship between adipocyte fatty acid-binding protein(A-FAB P)and insulin resistance in patients with nonalcoholic fatty liver.Methods Overall 119 patients with nonalcoholic fatty liver and 120 normal controls were choosed.Hight,weight,waistc ircum ference(WC),hip circum ference,body mass index(BMI),waist-to-hip ratio(WHR),triglyce ride,total cholesterol(TG),high density lipoprotein,fasting blood glucose(FBG),fasting blood insulin (FINS),homeostasis model assessment-insulin resistant index(NOMA-IR),and adipocyte fatty acid-binding prote in of the subjects were detected and compared.Results Compared with the control group,the lever of A-FABP increased (13.45±5.06 vs 9.14±5.00μg/L,P<0.01).The level of A-FABP had positive correlations with BMI,WC,W HR,HO-MA 2IR,FINS,FBG,TG,systolic blood pressure and diastolic blood pressure(r=0.560,0.538,0.384,0.426,0.341,0.345,0.256,0.359,P<0.01 for all),and negative correlation with high density lipoprotein-C(r=-01337,P<0.01).Conclusion Insulin resistance is present in patients with nonalcoholic fatty liver and correlates with the level of adipocy te fatty acid0binding protein.