Abstract: Objective To understand the knowledge of AIDS-related occupational exposure and HIV stigma and discrimination among quasi-medical staff for reducing HIV stigma and discrimination among quasi-medical staff.Methods In December 2009,343 senior students of clinical medicine and nursing who were about to the professional practice were randomly selected in Xiangnan university.A questionnaire survey was conducted among the quasi-medical personnel.Results There were 343 valid questionnaires collected.The cognitive rate of the quasi-medical staff to 9 problems about AIDS/HIV-related occupational exposure was 72.5%.For nine kinds of hypothetical circumstances having to contact with AIDS/HIV,93.6% of the respondents expressed that in at least one situation they feared casual transmission of HIV;74.1% of the subjects showed different level of stigma.There were 68.5% of the subjects would be ashamed of HIV infection.22.2% of the respondents expressed that it is no neccesary to keep HIV-infection secrecy for AIDS/HIV.83.4% of the respordents expressed that the patients with AIDS/HIV should be hospitalized only in the hospital of infectious diseases if needed.Among the subjects,60.3% indicated that they would look at the situation before making a decision weather they take medical treatment for the AIDS/HIV patients with wound.There were 4.1% of the subjects answered they would refuse to deal with the situation.Conclusion The quasi-medical staff are fear of daily contact with AIDS/HIV and there are serious HIV-related stigma and discrimination among the staff.