Abstract: ObjectiveTo explore the effects of seven nutrients on lead-induced neurotoxicity.MethodsLead poisoning model was made by giving the rats with 800mg/L of lead acetate in drinking water consecutively for four weeks.According to orthogonal design,7 nutrients were tested with animal experiments.The nutrients were tyrosine,glycolamine,methionine,taurine,vitamin C,vitamin B1 and Zinc.Four weeks later,the ability of learning and memory of the rats in each group was measured with Morris water maze test.Superoxide dismutase(SOD),nitric oxide sythase(NOS)activity and malondialdehyde(MDA),nitroge monoxide(NO)in hippocampus of the rats were also measured.ResultsOn the second and third day,the mean of the latent periods of the experimental group(21.41±14.14s,19.35±10.89s)were less than that of the positive control group(34.42±11.49s,32.48±15.06s;P<0.05).The activities of SOD,NOS and levels of NO were restored to normal levels by the intervention of the nutrients and the effects of taurine was the most obvious(R=85.30, 0.82,31.24;P<0.01 for all).ConclusionNutrients might reduce lead-induced impairment in hippocampus of rats.The ability of learning and memory could be improved by joint administration of multi-nutrients in rats with lead exposure.