Abstract: Objective To investig atetoxic effect of 8-hydroxy quinoline in water on fish embryo and larva.Methods Embryos at different stages and larvae of P.dabryanus(including blastoderm formed,mid-gastrulation,neurula stage,tail bud stage,and newly hatched fish stage)were treated with different concentrations of 8-hydroxy quino line to test the changes of embryo hatching rate,malformation rate,mortality,and the change in body length of larva.Results with the increase of 8-hydroxyquino line concentration,the hatching rate of P.dabryanusem bryos declined from 95% to 87%,78%,7415%,and 73%,and the abnomal rate of embryoincreased from 2% to 63%,75%,72%,and 64%,respectively.The mortality ratio of larval P.dabryanus increased from 4% to 100%.The body length of larva intreatment groups was shorter than that of the control group with a dose-effect relationship.Conclusion 8-hydroxy quinoline inhibits the development of P.dabryanus embryo and larva,with obvious tera to genic and lethale ffects.