Abstract: Objective To study the expression of cyclin D1 mRNA in esophageal cancer in Xinjiang Kazak.Methods RT-PCR was used to detect the mRNA of cyclin D1 in 48 esophageal cancer cases.Results The positive rate of cyclin D1 mRNA expre ssion in esophageal cancer tissues of 48 cases and normal tissues(adjacent non carcinoma tissues)were 95.75%(45/48)and 87.5%(42/48)without significant difference(P>0.05).The expression of cyclin D1 was no significant increase in cancer tissues compared to the normal tissues(P>0.05).The expression level of cyclin D1 mRNA was not significantly related to the degree of cell differentiation,depth of invasion and lymphnode meta stasis.Conclusion There sult suggests that the expression of cyclin D1 is not correlated with the degrees of differentiation,depth of invasion and lymphnode metastasis.The cyclin D1 gene expression in esophageal cancer needs to be studied.