Abstract: Objective To investigate serum levels of PFOS and PFOA in two occupational population in Wenzhou.Methods Workers in shoe and brick factories were selected as occupational exposure and non occupational exposure groups.The contents PFOS and PFOA in the serum of the workdrs were detected by means of liquid liquid extracti n and liquid phase chromatog raphy/mass spectrog raphse lectiveiron monitoring(PFOS:m/z=499,PFOA:m/z=413).Results The geometric mean(GM)of serum PFOS concentration in the shoe workers was 10.79 μg/L,signif icantly higher than that of in the brick workers(4.93μg/L).While the GM of serum PFOA concentration in the shoe workers was 2.98μg/L,significantly lower that of those in the brick workers(4.85μg/L).There was no significant difference between the gender of two groups workers in PFOS and PFOA burden levels.There was also no significant difference between the workers with<3 and≥3 years working time in shoe factories.Conclusion The PFOS and PFOA contaminations exist in serum of workers with occupational exposure in Wenzhou.