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周燕, 王绩凯, 黄凯, 李迎春. 脂肪肝患者肝功能与血脂水平关系[J]. 中国公共卫生, 2011, 27(1): 101-102. DOI: 10.11847/zgggws2011-27-01-51
引用本文: 周燕, 王绩凯, 黄凯, 李迎春. 脂肪肝患者肝功能与血脂水平关系[J]. 中国公共卫生, 2011, 27(1): 101-102. DOI: 10.11847/zgggws2011-27-01-51
ZHOU Yan, WANG Ji-kai, HUANG Kai, . Relationship between liver function and serum lipid among patients with fatty live[J]. Chinese Journal of Public Health, 2011, 27(1): 101-102. DOI: 10.11847/zgggws2011-27-01-51
Citation: ZHOU Yan, WANG Ji-kai, HUANG Kai, . Relationship between liver function and serum lipid among patients with fatty live[J]. Chinese Journal of Public Health, 2011, 27(1): 101-102. DOI: 10.11847/zgggws2011-27-01-51

脂肪肝患者肝功能与血脂水平关系

Relationship between liver function and serum lipid among patients with fatty live

  • 摘要: 目的 探讨脂肪肝患者肝功能、血脂变化特征以及两者之间的关系.方法 比较225例脂肪肝患者与187例正常对照的肝功能和血脂各指标检测结果,并对各项肝功能和血脂指标进行相关分析.结果 脂肪肝组的丙氨酸氨基转移酶(ALT)(49.49±42.87)U/L、天冬氨酸氨基转移酶(AST)(29.88±15.08)U/L、总胆固醇(TC)(5.06±0.92)mmol/L、甘油三酯(TG)(1.96±1.44)mmol/L、低密度脂蛋白胆固醇(LDL-c)(3.33±0.74)mmoI/L高于对照组,而AST/ALT(0.76±0.40)、高密度脂蛋白胆固醇(HDL-c)(1.30±0.25)mmol/L低于对照组.差异均具有统计学意义(P<0.005).相关分析结果显示,脂肪肝组TC与总蛋白(TP)、白蛋白(ALB)呈正相关;TG与AST、TP、ALB、球蛋白(GLB)呈正相关;LDL-c与AST/ALT呈正相关.结论 脂肪肝患者的肝功能、血脂特征主要表现为ALT增高、AST在正常参考值范围内的增高,以及各项血脂指标异常,且部分肝功能指标与血脂指标(主要是TC、TG)之间关系密切.

     

    Abstract: Objective To investigate the characteristics of liver function and serumlipid among patientswith fatty liver and to explore the relationship between them.Methods Liver function and serumlipid of 225 patients with fatty liver were compared with those of 187 normal controls, and the correlation between liver fuction and serumlipid was analyzed with Pearson analysis.Results The a lanine amino transferase(ALT)(49.49±42.87 U/L), aspartate amino transferase(AST)(29.88±15.08 U/L), total cholesterol(TC)(5.06±0.92 mmol/L), triglyceride(TG)(1.96±1.44 mmol/L), and lowdensity lipoprotein chole sterol(LDL-c)(3.33±0.74 mmol/L) of the fatty liver group were significantly higher than those of the control group.While AST/A LT(0.76±0.40) and high density lipopro teincholesterol(HDL-c)(1.30±0.25 mmol/L) were signif icantly lower(P < 0.005).Correlation analysis showed that in the fatty liver group, TC was positively corre lated with total protein(TP) and album in(AL B); TG was positively corre lated with AST, TP, ALB,GLB; LDL-c was positively correlated with AST/ALT.Conclusion Liver function and serumlipid characters of the patients with fatty liver present the increased levels of ALT and AST with in the normal reference range and abnorm a lities in serumlipid index.Some indicators of liver function relate closely to serumlipids, especially TC and TG.

     

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