Abstract: Objective To explore the effects of lycium and endurance training on liverce llular free radical metabolism and some biochemical indexes of inrats.Methods Sixty-four eight week old female rats were randomly assigned to 8 groups.The training groups were trained by progressive intensity endurance swmiming,and the medicine-treamtent groups were fed with lycium for 4 weeks.Then liver cellular free radical metabo lism and some biochemical indexes of the rats at rest and exhaustive were tested.Results The tmie of exhaustive swmiming could be significantly prolonged by 10.42% and 19.18% after taking lycium and training.Lycium could significantly increase the activity of liver pyruvic transaminase (GPT),cholinesterase(ChE),and the ratio of superoxide dismutase/malondialdehyde(P < 0.01) in rats at rest and endurance training.Lycium could decrese the content of blood glycogen and liver lactic acid(P < 0.01),while increase the content of liver glycogen in rest groups(P < 0.01).Effect of training on the trend of indexes in rats at exhaustive state was basically the same with lycium.Conclusion Lycium has a function of protecting liver,and endurance training can decrease liver damage.