Abstract: Objective To estimate the disease burden of malignant neoplasm among residents in Yancheng city for making intervention measures on malignant tumor and public health plan.Methods Data on malignant neoplasm mo rbidity and mortality among residents of Yancheng city in 2009 were collected and years of life lost(YLL), years lived with disability (YLLD), and disability-adjusted life year (DALY) were calculated with the tools provided by World Health Organization.Results The incidence and standardized incidence rate of malignant neoplasm among the residents were 282.60/100 000 and 217.5/100000; the mortality and standardized mortality rate were 215.81/100 000 and 150.02/100 000.The first five malignatnt tumors were stomach, esophageal, lung, liver, and colorectal cancer.The YLL, YLD, and DALY of malignant neoplasm was 27.41, 2.70, and 30.11 years per 1 000 person years(33.04, 3.28, 36.32 for male and 21.52, 2.07, 23.59 for female), respectively.The cancers with top four DALYs were liver, stomach, lung, and esophagus cancer with the DALY of 5.77, 5.67, 5.54, and 5.44 years per 1 000 person years.Most of the DALYs happened among the residents above 45 years old.The malignant tumors with the highest DALY for the residents at the age of 0-29, 30-59, 60-79, and ≥80 years were leukemia, liver, stomach, and esophageal cancer.Conclusion The disease burden of malignan tneoplasm is serious and liver, lung, stomach, and esophagus cancer are the major cancers among the residents in Yancheng city.