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徐彩红, 李仁忠, 陈明亭, 王黎霞, 蓝勇. 耐多药肺结核患者发现及治疗策略分析[J]. 中国公共卫生, 2011, 27(4): 391-393. DOI: 10.11847/zgggws2011-27-04-04
引用本文: 徐彩红, 李仁忠, 陈明亭, 王黎霞, 蓝勇. 耐多药肺结核患者发现及治疗策略分析[J]. 中国公共卫生, 2011, 27(4): 391-393. DOI: 10.11847/zgggws2011-27-04-04
XU Cai-hong, LI Ren-zhong, CHEN Ming-ting, . Strategy for multidrug resistant pulmonary tuberculosis case finding and treatment[J]. Chinese Journal of Public Health, 2011, 27(4): 391-393. DOI: 10.11847/zgggws2011-27-04-04
Citation: XU Cai-hong, LI Ren-zhong, CHEN Ming-ting, . Strategy for multidrug resistant pulmonary tuberculosis case finding and treatment[J]. Chinese Journal of Public Health, 2011, 27(4): 391-393. DOI: 10.11847/zgggws2011-27-04-04

耐多药肺结核患者发现及治疗策略分析

Strategy for multidrug resistant pulmonary tuberculosis case finding and treatment

  • 摘要: 目的通过分析耐多药肺结核患者发现和治疗情况,探索适合中国国情的耐多药肺结核患者发现及治疗策略。方法采用月报表、季报表收集患者发现、治疗及痰菌阴转数据,通过分析耐多药肺结核患者筛出率评价高危人群筛查的患者发现策略;通过分析标准化治疗方案使用情况以及6月末痰菌阴转情况,评价耐多药标准化治疗策略。结果耐多药2 657例可疑患者进行药敏试验,880例(33.1%)确诊为耐多药肺结核;其中经过治疗前体检和医生评估的814例患者,仅有473例(58.1%)纳入治疗,433例(91.5%)接受标准化治疗;完成6个月治疗的124例患者中,痰涂片和痰培养阴转率分别为67.7%和63.7%。结论耐多药肺结核高危人群筛查是适合中国目前技术能力和资源情况,符合成本效益的患者发现策略;标准化治疗方案能够满足大部分患者治疗需求,并获得理想的痰菌阴转率。

     

    Abstract: ObjectiveTo analyze multidrug resistant tuberculosis(MDR-TB)case finding and treatment and to explore the case-finding and treatment strategy suitable for situation in China.MethodsData on case-finding,treatment and sputum negative conversion were collected from monthly and quarterly reports and the ratio of confirmed MDR-TB cases among different high risk groups was analyzed to evaluate high risk groups screen strategy.The use of standardized regimen among all enrolled MDR-TB cases and the sputum conversion rate at the end of six month treatment were also analyzed to evaluate the feasibility of standardized treatment regimen in China.ResultsAmong the 2 657 MDR-TB suspects with drug susceptible test(DST),880(33.1%)were confirmed MDR-TB.Totally 814 MDR-TB cases received physical examination and medical evaluation;473(58.1%)cases were enrolled in the treatment;433(91.5%)cases received standardized regimen.Among 124 MDR-TB cases that finished 6 months treatment,the sputum smear and culture negative conversion rate was 67.7% and 63.7%,respectively.ConclusionHigh risk group screening strategy is a cost-effective strategy that feasible to the current technical capacity and resources in China.Standardized regimens adapt to most of the MDR-TB cases and could achieve ideal sputum negative conversion rate.

     

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