Abstract: ObjectiveTo investigate the effect of alcohol on ischemia-reperfusion(I-R)induced gastric mucosa injury in rats.MethodsThe rat model of gastric I-R injury and chronic alcohol drinking was established and the rats were randomly divided into 6 groups:normal sham operation group,alcohol drinking sham operation group,normal gastric I-R 1hr/2hr groups,and alcohol drinking gastric I-R 1hr/2hr groups.Gastric mucosal injury index was recorded.The contents of malondialdehyde(MDA)and the activity of superoxidase dismutase(SOD)in gastric mucosa were measured.The status of gastric mucosa cellula apoptosis was detected by TdT-mediated dUTP-biotin nick end labeling(TUNEL).ResultsI-R induced gastric mucosa injury(P<0.05).The gastric mucosa injury index was 106±12 and 74.4±11 after the reperfusion of 1 hr and 2 hr with the mucosal apoptosis rate of 73.2±6.5% and 54±7.4%,respectively.Compared with that of normal sham group,the content of MDA(7.98±2.1 nmol/mgprot)was significantly increased and the activity of SOD (141±16.1 U/mgprot)was reduced after gastric I-R of 1 hour.Gastric mucosal injury index(9.2±0.7)was increased after chronic alcohol intake.Chronic alcohol drinking didn't aggrevated I-R injury,but weakened the ability of gastric selfrepair.ConclusionAlcohol intake could reduce the activity of SOD and aggravate the oxidation and antioxidant balance disorders,and then weaken the ability of gastric self-repair.